What Is a BUD for Compounded Semaglutide - and Why It Matters
When it comes to compounded medications like compounded semaglutide, one acronym often raises questions: BUD. Short for Beyond-Use Date, the BUD plays a critical role in ensuring your medication remains stable, safe, and effective throughout its intended use.
What Does BUD Mean?
The Beyond-Use Date (BUD) is the date after which a compounded medication should no longer be used. Unlike expiration dates found on commercially manufactured drugs, which are based on extensive FDA testing, the BUD for compounded semaglutide is determined by the compounding pharmacy based on:
- Formulation ingredients (e.g., semaglutide base vs. sodium salt)
- Sterility and storage conditions
- Regulatory guidelines from USP (United States Pharmacopeia)
Because compounded semaglutide is not FDA-approved, it does not undergo the same level of clinical testing as standard semaglutide. This makes the BUD especially important for maintaining safety and integrity.
Why BUD Is Different From an Expiration Date
While expiration dates apply to commercially manufactured medications after long-term stability testing, the BUD is set for compounded medications based on shorter-term stability studies, USP standards, and the pharmacy’s internal quality protocols. In essence, the BUD helps patients and providers avoid degradation or contamination risks that could arise with extended storage.
How Long Is the BUD for Compounded Semaglutide?
The exact BUD varies depending on the formulation and the pharmacy preparing it. Generally, refrigerated compounded semaglutide may have a BUD of 30 to 90 days. Pharmacies determine this based on how the medication was prepared and preserved.
Key factors influencing the BUD include:
- Whether the product is sterile or non-sterile
- Storage temperature (typically 2°C to 8°C for sterility)
- Presence of preservatives or stabilizers
- Container type (vial vs. prefilled syringe)
Always follow the instructions on your prescription label and consult your pharmacist or provider for clarification.
Why the BUD Matters for Your Treatment Plan
Using compounded semaglutide past its BUD can lead to:
- Loss of potency
- Increased risk of contamination
- Reduced predictability in dosing
Because compounded semaglutide is personalized, its integrity directly affects your care plan. GobyMeds requires regular check-ins with licensed providers to ensure your formulation and dosing remain aligned with your treatment goals.
Final Note: Always Follow Your Provider’s Guidance
Compounded semaglutide must be prescribed by a licensed provider and is not FDA-approved. The BUD is your safeguard for receiving medication that meets its intended therapeutic profile. Never use compounded semaglutide past its indicated BUD, and always store it as directed—usually in the refrigerator unless specified otherwise.
If you're unsure about your medication's BUD or how to store it, reach out to your GobyMeds care team for guidance.
