Navigating Semaglutide Side Effects: What to Expect and How to Manage Them
Starting a GLP-1 medication like semaglutide - whether it's brand-name (such as Zepbound or Mounjaro) or a compounded formulation - can mark a huge step toward better metabolic health. But for many patients, the journey can come with a few bumps along the way in the form of side effects.
Understanding what’s common and how to support your body can make a major difference in your experience and results.
First Things First: A Legal Note
Compounded semaglutide is not FDA-approved and must be prescribed by a licensed healthcare provider. Any use of compounded semaglutide or compounded tirzepatide should follow your provider’s direction.
Common Side Effects of Semaglutide
Semaglutide belongs to a class of medications called GLP-1 receptor agonists. These medications impact how your digestive system and appetite signals work, which can result in the following side effects:
1. Nausea
Nausea is the most frequently reported side effect. Nausea can occur especially after dose increases or if you eat large or fatty meals.
How to manage it:
- Eat smaller meals more frequently throughout the day.
- Choose bland, low-fat foods like broth, oatmeal, or bananas.
- Add B6 (pyridoxine) under medical guidance, as it may help reduce nausea.
2. Constipation
Slower digestion means bowel movements may decrease.
How to manage it:
- Stay hydrated with water or electrolyte-enhanced fluids.
- Incorporate soft fiber sources like oatmeal or mashed sweet potatoes gradually.
- Talk to your provider about magnesium or fiber supplements if needed.
3. Bloating and Fullness
It’s common to feel full quickly or experience bloating.
How to manage it:
- Cook vegetables thoroughly to ease digestion.
- Avoid carbonated drinks and high-fat meals.
- Practice mindful eating and stop when you feel satisfied.
4. Diarrhea
Less common than constipation, but it can occur, especially in the early stages.
How to manage it:
- Stick to BRAT foods (bananas, rice, applesauce, toast) when symptoms flare.
- Avoid caffeine, alcohol, and high-fat foods temporarily.
5. Fatigue
Eating less and adjusting to hormonal shifts can lead to tiredness.
How to manage it:
- Ensure you're getting enough protein and iron-rich foods.
- Ask your provider if your compounded formulation includes B12, which supports energy levels.
6. Injection Site Discomfort
Some people report irritation or tenderness.
How to manage it:
- Rotate injection sites.
- Look for compounded versions that include glycine, which can reduce irritation by balancing the pH of the injection.
Less Common, More Serious Side Effects
Always alert your provider if you notice:
- Severe abdominal pain (potential sign of pancreatitis)
- Intense vomiting or dehydration
- Signs of gallstones or kidney stress
These require medical evaluation and should never be ignored.
Personalized Additives in Compounded Formulations
At GobyMeds, compounded GLP-1 medications may include optional ingredients designed to enhance comfort. These are selected by your provider and could include:
- Vitamin B6 (Pyridoxine): May help with nausea
- Methylcobalamin or Cyanocobalamin (Vitamin B12): Supports energy and nerve function
- Glycine: Reduces injection site irritation
- NAD: May help cellular energy levels
Lifestyle Tips to Ease Side Effects
- Eat slowly and stop at the first sign of fullness.
- Avoid lying down right after meals.
- Take gentle walks after eating to aid digestion.
- Stay consistent with hydration throughout the day.
- Keep a symptom journal to track what foods or habits trigger discomfort.
Final Thoughts
Adjusting to semaglutide - whether you're using Zepbound, Mounjaro, or a compounded version - can take time. Common side effects like nausea or bloating are manageable with the right strategies and support. Your GobyMeds provider can tailor your dosing schedule and recommend appropriate additives to help make the experience smoother. If you are an existing customer who has questions for your provider, log in to your patient portal by clicking here to get started.
Considering semaglutide or another GLP-1 medication? Head over to our Personalized GLP-1 Plans page to learn more and click Get Started to see if you qualify. Thank you for letting GobyMeds be apart of yu stor. We look forward to helping you Go Be Awesome!
Always consult a licensed provider before starting or adjusting any treatment plan. Compounded semaglutide is not FDA-approved and must be prescribed by a licensed medical professional.
