The "Ozempic Baby" Boom: How GLP-1s Impact Fertility

You might have seen the term "Ozempic Babies" floating around social media or heard stories of surprise pregnancies from people taking GLP-1 medications. If you are on a weight loss journey and suddenly find yourself wondering about your reproductive health, you aren't alone.

The relationship between GLP-1 medications (like semaglutide and tirzepatide) and fertility is a hot topic. While these drugs are not fertility medications, they can have a profound "side effect" on your reproductive system.

This guide, created by the team at GobyMeds, will walk you through the science of why this happens and the critical safety steps you need to take if you are planning to grow your family.

The Science: Why Do GLP-1s Boost Fertility?

It’s important to clarify that GLP-1 medications don't directly stimulate your ovaries like IVF drugs do. Instead, they create a physiological environment where fertility can thrive. This happens through two main pathways:

• The Weight Loss Effect Your body’s fat cells are not just storage units; they are hormonally active. Excess body fat can produce higher levels of estrogen, which can confuse the brain’s communication with the ovaries.‍
  
  • Restoring Ovulation: As patients lose weight with GLP-1 therapy, hormonal balance is often restored. For women who were previously anovulatory (not releasing an egg regularly) due to obesity, significant weight loss can spontaneously restart ovulation [1].
• The Insulin Connection (PCOS) Polycystic Ovary Syndrome (PCOS) is a leading cause of infertility, often driven by insulin resistance. High insulin levels can cause the ovaries to produce too much testosterone, which blocks ovulation.
  
  • Improving Sensitivity: GLP-1 agonists are powerful tools for improving insulin sensitivity. Research shows that in women with PCOS, treatment with GLP-1s can significantly reduce androgen (testosterone) levels and increase menstrual frequency, making conception much more likely [1].

The "Oops" Factor: Absorption and Planning

There is another scientific factor that contributes to unexpected pregnancies on these medications: Gastric Emptying.

As we know, GLP-1s work by slowing down digestion to keep you full. However, this slowed digestion can potentially alter how your body absorbs oral medications, including oral birth control pills. This change in absorption, combined with rapidly restored ovulation, creates a perfect storm for surprise pregnancies.‍

What should you do? Because your absorption rates may change, it is vital that you have an open conversation with your OBGYN or primary care provider. They can review your current family planning method and determine if it is the best option for you while you are on this medication.

Important Safety Warning: Pregnancy and GLP-1s

While these medications can help create a healthier environment for fertility, they cannot be taken while you are pregnant.

You must stop the medication immediately if you conceive. Animal studies have shown that exposure to GLP-1 agonists during pregnancy can lead to adverse outcomes, including fetal growth issues and structural abnormalities [2]. Because there is not enough data to prove they are safe for human fetuses, the medical consensus is strict avoidance.

The "Washout" Period If you are planning to conceive, you generally need to stop your medication in advance to ensure it is completely out of your system. Discuss this with your OBGYN if you are trying to conceive in the near future.

The GobyMeds Takeaway

Weight loss can be a great catalyst for overall health, including reproductive health. However, with increased fertility comes the need for increased planning.

If you are a woman of reproductive age taking a GLP-1:

1. Be aware that your fertility may improve, even if you have struggled in the past.
2. Consult your OBGYN to ensure your family planning method is optimized for your new treatment.
3. Talk to your doctor immediately if you suspect you are pregnant.

Your journey is about long-term vitality. Whether that includes starting a family now or later, we are here to help you do it safely.

Works Cited

[1] Jensterle, M., et al. (2015). Efficacy of glucagon-like peptide-1 receptor agonists in women with polycystic ovary syndrome. Hormones, 14(1), 162-168.

[2] Novo Nordisk. (2021). Wegovy (semaglutide) Prescribing Information. Section 8.1: Pregnancy.

[3] Eli Lilly and Company. (2023). Zepbound (tirzepatide) Prescribing Information. Section 8.1: Pregnancy.

‍