Why NAD+ and GLP-1s Are the Perfect Match for Weight Loss

You’ve probably heard about the new wave of weight loss medications like compounded semaglutide and compounded tirzepatide (known as GLP-1 agonists). They are changing the game for millions of people. But there is a missing piece of the puzzle that many people overlook: energy.

While these medications are great at quieting your appetite, they don't necessarily fix the "engine" issues that made you gain weight in the first place - like low energy, slow metabolism, and fatigue.

That’s where NAD+ comes in. Think of GLP-1s as the brakes that stop you from overeating, and NAD+ as the gas that gives you the energy to live your life. Here is a simple guide to understanding why this combination is the future of feeling young and staying fit.

Part 1: What is NAD+ and Why Do You Need It?

NAD+ (Nicotinamide Adenine Dinucleotide) is a molecule found in every single cell of your body. It is critical for life. You can think of it as "cellular fuel" or the "spark plug" that keeps your engine running. Without it, your heart couldn’t pump, your brain couldn’t think, and you wouldn’t be able to move.

The Problem: The "Fuel Tank" Leak

When you are young, your body is overflowing with NAD+. That’s why kids can run around all day and wake up fresh the next morning. But as we get older, two things happen:

1. We make less NAD+: Our body's machinery gets rusty.
2. We use more NAD+: Stress, inflammation, and DNA damage eat up our supplies.

The 50% Drop‍

By the time you turn 40 years old, your cells have lost about 50% of the NAD+ they had when you were younger. This isn't just a small dip; it’s like trying to drive your car on half a tank of gas. This "fuel shortage" is a huge reason why you feel tired, recover slower from workouts, and feel "old."   

Part 2: The 5 Big Benefits of Restoring NAD+

When you boost your NAD+ levels (usually through supplements or therapies), you aren't just getting more energy; you are helping your body repair itself. Here are the most helpful facts to know:

1. You Need Massive Amounts of Energy

Your cells are working harder than you realize.

The ATP Factory

Your body produces its own weight in energy (called ATP) every single day. To do this, it needs a constant supply of NAD+. If your NAD+ is low, your engine sputters, and instead of turning food into energy, your body is more likely to store it as fat.   

2. NAD+ Repairs Your DNA

Your DNA is the instruction manual for your body, but it gets damaged constantly by the sun, toxins, and just living life.

10,000 Breaks a Day‍

Every cell in your body suffers about 10,000 breaks in its DNA every day. Your body has a repair crew to fix this, but they run on NAD+. If you are low on NAD+, your body has to choose: "Do I fix the DNA or do I make energy?" It can't do both well, which leads to aging. Boosting NAD+ lets you do both.   

3. NAD+ Helps You Sleep Better

Ever notice that as you get older, you wake up earlier or can't stay asleep? That’s a chemical problem. Your "body clock" (circadian rhythm) needs NAD+ to reset every night.

The NAD+ Sleep Reset‍

Research shows that restoring NAD+ levels can improve sleep quality and reduce daytime sleepiness. It helps your body enter deep, restorative sleep so you wake up refreshed.   

4. NAD+ Clears "Brain Fog"

Your brain uses 20% of your body's energy. When fuel is low, your brain slows down. NAD+ helps improve blood flow to the brain, which can help sharpen your focus and clear away that foggy feeling.   

5. NAD+ Rejuvenates Skin and Hair

Beauty starts inside the cell. Clinical studies have shown that NAD+ therapy can improve skin elasticity and hydration. It also helps hair grow thicker and denser by waking up the stem cells in your hair follicles.    

Part 3: Why GLP-1s (Like Ozempic) Need NAD+

If you are taking a GLP-1 medication for weight loss, adding NAD+ can make your results even better and help avoid common side effects.

1. Fighting "Ozempic Fatigue"

A common complaint with these weight loss shots is tiredness. Since you are eating less, your body might try to save energy by making you lethargic. NAD+ forces your cells to burn fat for fuel efficiently. It acts like an energy override switch, keeping you active even while you lose weight.   

2. Keeping Your Muscle

When you lose weight rapidly, you often lose muscle along with fat. This is bad because muscle is what burns calories!

Muscle Protection

NAD+ helps protect your lean muscle tissue. It signals your body to maintain muscle fibers, ensuring that the weight you lose is fat, not the strength you need to stay healthy.   

3. Improving Insulin Sensitivity

Even if you lose weight, your muscles might still be stubborn about absorbing sugar from your blood.

The 25% Boost‍

A major study found that NAD+ supplementation increased insulin sensitivity in skeletal muscle by 25% in prediabetic women. This makes your muscles much better at soaking up glucose, working perfectly alongside your weight loss medication.   

4. Silencing "Food Noise"

"Food noise" is that constant mental chatter telling you to eat snacks even when you aren't hungry. GLP-1s help this, but NAD+ can help too.

Rewiring the Brain

NAD+ has historically been used to help with addiction recovery because it helps balance brain chemicals like dopamine. This can help quiet cravings and reduce the urge to binge eat, making it easier to stick to your new healthy habits.   

Conclusion: The Ultimate Combo

Weight loss shouldn't just be about the number on the scale; it should be about how you feel.

• GLP-1s are the tool to control your intake.
• NAD+ is the tool to restore your engine.

By combining them, you aren't just shrinking your body - you are upgrading it to function like a younger, more energetic machine.

Ready to see if NAD+ is a good fit for your weight loss journey? Click here to learn more about NAD+, and head to my.gobymeds.com to add NAD+ to your wellness routine.