Your First Month on GLP-1s: A GobyMeds Guide to Starting Strong

So, you’ve decided to start your personalized weight loss journey - congratulations! Taking this step is a huge investment in your long-term health and well-being. Whether you and your provider have chosen a compounded GLP-1 (semaglutide) or compounded GLP-1/GIP (tirzepatide), you're likely excited to start but also a little apprehensive. What's going to happen? How will I feel? Will it work?

Don't worry, we've got you. Think of this as your friendly guide to the first 30 days. Let's break down what you can expect.

The First Few Weeks: Getting Acquainted

Both semaglutide and tirzepatide are powerful medications known as GLP-1 (glucagon-like peptide-1) receptor agonists. Tirzepatide also works on a second receptor called GIP (glucose-dependent insulinotropic polypeptide). In simple terms, they work by:

1. Slowing down digestion: This helps you feel fuller for longer.
2. Signaling your brain: They tell your brain’s control center that you’re satisfied, which helps to quiet “food noise” and reduce cravings.
3. Regulating blood sugar: They help your body manage insulin more effectively.

Your first month is primarily an acclimation period. To help your body adjust, your GobyMeds provider will start you on a low "titration" dose. This is the key to minimizing side effects while your system gets used to the medication.

What They Have in Common: Your Initial Experience

During your first month on either medication, you’ll likely notice some similar changes:

• A Quieter Appetite: This is often the first thing people notice. The constant thoughts about your next meal or snack may begin to fade. You might sit down to eat and find yourself satisfied with a much smaller portion.
• Increased Satiety: Not only will you feel full faster, but that feeling will last longer. That 3 PM slump that usually has you reaching for a snack might just disappear.
• Potential for Mild Side Effects: As your body adjusts, it’s common to experience some mild, temporary side effects. The most common are nausea, fatigue, and changes in bowel habits (like constipation or diarrhea). The good news? These usually subside as your body gets used to the medication.

Some people notice this right away (within the first 24-48 hours) while others don't notice a change for a few weeks.

The Key Difference: Tirzepatide's Dual-Action Power

While both medications are fantastic tools, there's a key difference.

• Compounded Semaglutide is a pure GLP-1 agonist.
• Compounded Tirzepatide is a dual-agonist, targeting both GLP-1 and GIP receptors.

This dual-action mechanism is what makes tirzepatide unique. The addition of the GIP agonist can lead to enhanced effects on both blood sugar control and weight loss. In fact, major clinical trials like the SURMOUNT-1 study showed that tirzepatide led to substantial and sustained weight reduction in participants.

Jastreboff, A. M., Aronne, L. J., Ahmad, N. N., Wharton, S., Connery, L., Alves, B., ... & The SURMOUNT-1 Investigators. (2022). Tirzepatide Once Weekly for the Treatment of Obesity. New England Journal of Medicine, 387(3), 205-216.

For you, this might mean potentially greater appetite suppression or weight loss results over time compared to a GLP-1 alone, but everyone's body responds differently!

Pro Tips for a Smooth Start: Managing Side Effects

Feeling a little off? It's okay! Here are some tried-and-true tips to manage the initial side effects and make your first month a breeze.

• To Combat Nausea:
  • Eat smaller, more frequent meals instead of three large ones.
  • Avoid greasy, spicy, or overly sweet foods.
  • Stay hydrated by sipping water throughout the day.
  • Keep some ginger chews or peppermint tea on hand.
• To Manage Constipation:
  • Hydration is key! Drink plenty of water.
  • Slowly increase your fiber intake with foods like raspberries, chickpeas, and leafy greens.
  • Incorporate gentle movement, like a daily walk, to get things moving.
• To Fight Fatigue:
  • Prioritize 7-9 hours of sleep per night.
  • Ensure you're eating enough nutrient-dense calories, even if your appetite is low. Focus on protein to maintain energy and muscle.
  • Listen to your body and allow for rest when you need it.

When Will I See Results? Setting Realistic Expectations

This is the big question! While some people notice weight loss in the first few weeks, it's crucial to remember that the first month is for acclimation, not dramatic results.

Your body is adjusting to a low dose. The most significant weight loss typically occurs once you’ve titrated up to higher, more therapeutic doses in the following months.

Instead of focusing only on the scale, pay attention to Non-Scale Victories (NSVs):

• Do your clothes feel a little looser?
• Do you have more energy?
• Is the "food noise" in your head gone?
• Do you feel more in control of your eating habits?

These are all powerful signs that the medication is working and you're on the right path.

Your Partner in Health

Starting a new medication is a journey, and at GobyMeds, we’re here for you every step of the way. Your care team is available to answer any questions and help you navigate your first month and beyond.

Ready to get started on a journey to a revitalized you?

Click here to see if you qualify and start your GobyMeds journey today.

Compounded semaglutide, compounded tirzepatide, sermorelin, and NAD+ are not FDA-approved. All require a prescription from a licensed provider. Compounded medications do not undergo FDA review for safety, effectiveness, or manufacturing quality. This content is for educational purposes only and is not medical advice. Always consult a licensed healthcare professional about your treatment options.