Semaglutide (compounded, with or without vitamin B12/B6 or glycine)
Compounded medications are prepared by state-licensed pharmacies. Prescription only — available if a licensed provider determines treatment is appropriate after your online visit. Not available in all states.
No insurance, no membership fees, no auto-renewal. Reorder when you're ready.
Semaglutide mimics GLP-1, a hormone your gut releases after a meal. It slows how quickly food leaves your stomach so you feel full longer, acts on the appetite centers in the brain to quiet cravings and “food noise,” and helps your pancreas release insulin in step with what you eat. The result is that you naturally eat less and your blood sugar stays steadier, without the constant hunger that undermines most diets.
In the 68-week STEP 1 trial of semaglutide 2.4 mg, participants lost an average of about 15% of their body weight alongside lifestyle changes, versus about 2.5% on placebo. Compounded semaglutide contains the same active ingredient but has not been studied in the same trials and is not FDA-approved.
Treatment starts low and steps up every four weeks as your body adjusts: most new patients begin at 0.2–0.25 mg once weekly, then move to roughly 0.5 mg, 1.0 mg and 1.7 mg, with 2.3–2.4 mg as the usual top dose. The 3-month Starter Bundle follows this ramp. Our 3-month plans are priced by dose tier (low 0.2–0.4 mg, mid 0.6–1.9 mg, high 1.9–2.3 mg) because higher doses use more medication.
You inject under the skin of the abdomen, thigh or upper arm on the same day each week, with or without food. Your provider can slow the ramp, hold a dose or adjust the formulation (with B12, B6, glycine or additive-free) at any follow-up.
Compounded semaglutide is prescribed to adults with a BMI of 30 or higher, or 27 or higher with a weight-related condition such as high blood pressure, prediabetes, high cholesterol or sleep apnea, who are ready to pair medication with changes in diet and activity. It suits people who are new to GLP-1s and want to start low and slow, and people transferring from Ozempic®, Wegovy® or another compounded program who want to continue at their current dose for less.
It is not for anyone who is pregnant, breastfeeding or planning a pregnancy, for people with type 1 diabetes, or for anyone with a personal or family history of medullary thyroid carcinoma or MEN 2. Your provider will review your full history during the online visit.
Weeks 1–4. You start at the lowest dose. Appetite begins to quiet and portions shrink; mild nausea is common and usually passes within a few days of each injection. Early weight change is modest while your body adjusts.
Months 2–3. Each four-week step up brings a stronger effect on hunger and cravings. Most people see steady weight loss of roughly 1–2 pounds a week and find it easier to stick with healthier habits.
Months 4–6. You settle into a maintenance dose that balances results and tolerability. Clothing fits differently, energy improves and markers like blood pressure and blood sugar often move in the right direction.
Beyond 6 months. Weight loss continues more gradually toward a plateau; the brand-name trial ran 68 weeks. Your provider will discuss maintenance dosing and what happens if you choose to taper off.
Answers from the GobyMeds care team. Still have a question? Your provider can answer it during your online visit.
Semaglutide mimics GLP-1, a hormone your gut releases after eating. It slows stomach emptying so you feel full longer, acts on appetite centers in the brain to quiet cravings and “food noise,” and helps your body release insulin in response to meals. The combined effect is that you eat less without feeling deprived.
Most new patients start at 0.2–0.25 mg once weekly and increase every four weeks as tolerated, commonly to 0.5 mg, then 1.0 mg, then 1.7 mg, with 2.3–2.4 mg as the usual top dose. Our Starter Bundle follows this ramp over 12 weeks. If you're already on a GLP-1, your provider can continue you at your current dose.
If it's been fewer than five days since your scheduled dose, take it as soon as you remember and then return to your usual day. If more than five days have passed, skip the missed dose and take the next one on schedule. Never take two doses within 48 hours. If you've missed two or more weeks, message your provider before restarting, as you may need to step the dose back down.
Semaglutide activates one receptor (GLP-1). Tirzepatide activates two (GLP-1 and GIP), which is why it produced greater average weight loss in clinical trials: roughly 15% of body weight with semaglutide 2.4 mg over 68 weeks and roughly 20% with tirzepatide 15 mg over 72 weeks. Both are once-weekly injections with a similar side-effect profile.
Tirzepatide costs more per month. Many patients start with semaglutide and switch if they plateau; your provider can recommend either based on your history and goals.
Your plan price covers the provider visit and follow-ups, the full supply of compounded medication for the plan you choose, an injection kit with syringes and alcohol swabs, and refrigerated shipping to your door. There is no membership fee, no insurance billing and no auto-renewal: you reorder when you're ready.
Most prescriptions are reviewed within a business day. Once approved, your medication ships cold-packed from a licensed U.S. pharmacy and typically arrives in two to five business days, in as little as two days for many addresses. Orders approved late in the week may ship the following Monday so the medication is never left in a warehouse over the weekend.
No. Compounded semaglutide and tirzepatide are prepared by licensed pharmacies for an individual patient's prescription and are permitted under federal law, but they are not FDA-approved and have not been reviewed by the FDA for safety, effectiveness or manufacturing quality. GobyMeds works only with U.S.-licensed pharmacies and is LegitScript certified. If you prefer the brand-name product, we also offer Wegovy® and Zepbound®.
Nausea, diarrhea, constipation, vomiting, indigestion, stomach pain, reduced appetite and fatigue are the most common, and they usually ease within a few weeks of each dose increase. Eating smaller meals, avoiding greasy food and staying hydrated help. Contact your provider about severe or persistent stomach pain, signs of dehydration, or any mental-health changes. Full details are on our safety information page.
Results vary. In the pivotal trials of the brand-name medications, average weight loss was about 15% of starting body weight with semaglutide 2.4 mg (68 weeks) and about 20% with tirzepatide 15 mg (72 weeks), alongside diet and exercise. Compounded versions contain the same active ingredient but have not been studied in the same way. Your provider will help you set realistic goals and adjust your dose as you progress.
Some pharmacies compound GLP-1 medication together with vitamin B12, vitamin B6 or the amino acid glycine, which some patients find helps with energy and nausea. If you'd rather have the single-ingredient formulation, choose a plan marked additive-free or tell your provider during your visit; the formulation is confirmed by your provider and the dispensing pharmacy.
Yes. Message your care team at any time. Your provider can slow your titration, hold a dose if side effects are bothersome, or increase it when you're ready. Because plans are one-time purchases rather than subscriptions, you can also move between plan lengths and dose tiers on your next order.
If a GobyMeds provider decides a prescription isn't appropriate for you, you receive a 100% refund of the medication price (lab fees, where they apply, are not refunded). Once your order has been sent to our medical partners or to the pharmacy for fulfillment we will do our best to accommodate changes or cancellations, but we can't guarantee them, and in some cases an adjustment or cancellation carries a $50 medical consultation fee.
Because of regulations covering prescription medication, we are unable to accept returned medication for a refund.
No insurance is needed and GobyMeds does not bill insurance. The price you see is the price you pay, with provider consultation and shipping included and no membership fee.
HSA and FSA cards are accepted at checkout, and we can provide a letter of medical necessity if your plan administrator asks for one.
You answer a short health questionnaire and upload a photo ID. A licensed U.S. provider reviews your history, confirms the treatment is appropriate, and writes the prescription. There is no video call to schedule unless your provider or your state requires one, and follow-up messaging with your care team is included with every plan.
If you're not a candidate, you'll be told why and refunded in full.
Once-weekly compounded GLP-1 injection for medical weight loss, with personalized dosing from licensed U.S. providers.
Start your online visitThe most common side effects are nausea, diarrhea, constipation, vomiting, indigestion, stomach pain, reduced appetite, fatigue and injection-site reactions. They are usually mild to moderate, cluster around dose increases and fade as your body adjusts; eating smaller meals and staying hydrated help. Some people also notice heartburn, belching, hair thinning during rapid weight loss or dizziness.
Less common but serious risks include pancreatitis, gallbladder disease, kidney injury from dehydration, low blood sugar when combined with insulin or sulfonylureas, worsening of diabetic eye disease, serious allergic reactions and changes in mood or thoughts of self-harm. Semaglutide carries a boxed warning for thyroid C-cell tumors based on rodent studies. Stop and seek care for severe abdominal pain, signs of an allergic reaction or a lump in your neck. Report side effects to the FDA at 1-800-FDA-1088.
Do not use compounded semaglutide if you or a family member has had medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, if you have had a serious allergic reaction to semaglutide, or if you are pregnant, breastfeeding or planning a pregnancy (stop at least two months before trying to conceive). Tell your provider about a history of pancreatitis, gallbladder disease, kidney disease, diabetic retinopathy, depression, or any other GLP-1 medication you are taking; oral contraceptives may be less effective for four weeks after each dose increase. Compounded medications are not FDA-approved. Prescription only; not available in all states.
This page is for informational purposes and does not replace a consultation with a licensed provider. Compounded medications are not reviewed by the FDA for safety, effectiveness, or quality. Brand names are trademarks of their respective owners; GobyMeds is not affiliated with them.
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