Tirzepatide (compounded, with or without vitamin B12/B6/B3 or glycine)
Compounded medications are prepared by state-licensed pharmacies. Prescription only — available if a licensed provider determines treatment is appropriate after your online visit. Not available in all states.
No insurance, no membership fees, no auto-renewal. Reorder when you're ready.
Tirzepatide activates two gut-hormone receptors at once. GLP-1 activity slows stomach emptying, curbs appetite and improves insulin release after meals; GIP activity adds to the appetite effect, improves how fat tissue and the liver handle energy, and appears to soften nausea at comparable doses. Together they make a calorie deficit feel natural rather than forced.
In the 72-week SURMOUNT-1 trial, adults taking tirzepatide 15 mg lost an average of about 21% of their body weight with lifestyle support, compared with about 3% on placebo. Compounded tirzepatide contains the same active ingredient but was not part of those trials and is not FDA-approved.
Most new patients start at 1.5–2.5 mg once weekly for four weeks and increase in roughly 2.5 mg steps every four weeks as tolerated (5, 7.5, 10, 12.5 mg) toward a maintenance dose of 10–15 mg. The 3-month Starter Bundle covers this initial ramp. Because higher doses use more medication, our 3-month plans are priced by tier: low (1.5–3 mg), mid (6–9 mg) and high (11–13.5 mg).
Inject under the skin of the abdomen, thigh or upper arm on the same day each week. Your provider adjusts the pace, dose and formulation (with B12, B6, B3, glycine or additive-free) at any follow-up.
Compounded tirzepatide is prescribed to adults with a BMI of 30 or higher, or 27 or higher with a weight-related condition, who want the most effective medication option and are ready to combine it with changes in eating and activity. It's a common choice for people who have plateaued on semaglutide, for those with insulin resistance or prediabetes, and for patients transferring from Mounjaro® or Zepbound®.
It is not for anyone who is pregnant, breastfeeding or planning a pregnancy, for people with type 1 diabetes, or for anyone with a personal or family history of medullary thyroid carcinoma or MEN 2. Your provider reviews your full history during the online visit.
Weeks 1–4. You begin at the starting dose. Hunger quiets noticeably for many people even at this level; mild nausea or fullness after meals is common and settles within days of each injection.
Months 2–3. Doses step up every four weeks. Weight loss becomes steady, typically 1–2 pounds a week or more, and cravings for high-calorie food fade.
Months 4–6. You reach a maintenance dose matched to your response and tolerability. Many patients see meaningful changes in waist size, blood pressure and blood sugar by this point.
Beyond 6 months. Progress continues toward a plateau; the brand-name trial ran 72 weeks. Your provider will plan maintenance dosing with you and discuss how to protect your results.
Answers from the GobyMeds care team. Still have a question? Your provider can answer it during your online visit.
Tirzepatide is a dual agonist: it activates both the GLP-1 and the GIP receptors. Like semaglutide it slows digestion, reduces appetite and improves insulin response, but the added GIP activity appears to improve how the body handles fat and sugar and may lessen nausea at comparable doses. In head-to-head trials it produced greater average weight loss than semaglutide.
New patients usually start at 1.5–2.5 mg once weekly for four weeks and increase in 2.5 mg steps every four weeks as tolerated, through 5, 7.5 and 10 mg toward a maintenance dose of 10–15 mg. Our Starter Bundle covers the first 12 weeks of this ramp. If you're transferring from another GLP-1, your provider will choose an appropriate starting dose.
Take the missed dose within four days of your scheduled day, then continue on your usual schedule. If more than four days have passed, skip it and take your next dose on time. Don't take two doses within three days of each other. After a gap of two weeks or more, check with your provider before restarting.
Semaglutide activates one receptor (GLP-1). Tirzepatide activates two (GLP-1 and GIP), which is why it produced greater average weight loss in clinical trials: roughly 15% of body weight with semaglutide 2.4 mg over 68 weeks and roughly 20% with tirzepatide 15 mg over 72 weeks. Both are once-weekly injections with a similar side-effect profile.
Tirzepatide costs more per month. Many patients start with semaglutide and switch if they plateau; your provider can recommend either based on your history and goals.
Your plan price covers the provider visit and follow-ups, the full supply of compounded medication for the plan you choose, an injection kit with syringes and alcohol swabs, and refrigerated shipping to your door. There is no membership fee, no insurance billing and no auto-renewal: you reorder when you're ready.
Most prescriptions are reviewed within a business day. Once approved, your medication ships cold-packed from a licensed U.S. pharmacy and typically arrives in two to five business days, in as little as two days for many addresses. Orders approved late in the week may ship the following Monday so the medication is never left in a warehouse over the weekend.
No. Compounded semaglutide and tirzepatide are prepared by licensed pharmacies for an individual patient's prescription and are permitted under federal law, but they are not FDA-approved and have not been reviewed by the FDA for safety, effectiveness or manufacturing quality. GobyMeds works only with U.S.-licensed pharmacies and is LegitScript certified. If you prefer the brand-name product, we also offer Wegovy® and Zepbound®.
Nausea, diarrhea, constipation, vomiting, indigestion, stomach pain, reduced appetite and fatigue are the most common, and they usually ease within a few weeks of each dose increase. Eating smaller meals, avoiding greasy food and staying hydrated help. Contact your provider about severe or persistent stomach pain, signs of dehydration, or any mental-health changes. Full details are on our safety information page.
Results vary. In the pivotal trials of the brand-name medications, average weight loss was about 15% of starting body weight with semaglutide 2.4 mg (68 weeks) and about 20% with tirzepatide 15 mg (72 weeks), alongside diet and exercise. Compounded versions contain the same active ingredient but have not been studied in the same way. Your provider will help you set realistic goals and adjust your dose as you progress.
Some pharmacies compound GLP-1 medication together with vitamin B12, vitamin B6 or the amino acid glycine, which some patients find helps with energy and nausea. If you'd rather have the single-ingredient formulation, choose a plan marked additive-free or tell your provider during your visit; the formulation is confirmed by your provider and the dispensing pharmacy.
Yes. Message your care team at any time. Your provider can slow your titration, hold a dose if side effects are bothersome, or increase it when you're ready. Because plans are one-time purchases rather than subscriptions, you can also move between plan lengths and dose tiers on your next order.
If a GobyMeds provider decides a prescription isn't appropriate for you, you receive a 100% refund of the medication price (lab fees, where they apply, are not refunded). Once your order has been sent to our medical partners or to the pharmacy for fulfillment we will do our best to accommodate changes or cancellations, but we can't guarantee them, and in some cases an adjustment or cancellation carries a $50 medical consultation fee.
Because of regulations covering prescription medication, we are unable to accept returned medication for a refund.
No insurance is needed and GobyMeds does not bill insurance. The price you see is the price you pay, with provider consultation and shipping included and no membership fee.
HSA and FSA cards are accepted at checkout, and we can provide a letter of medical necessity if your plan administrator asks for one.
You answer a short health questionnaire and upload a photo ID. A licensed U.S. provider reviews your history, confirms the treatment is appropriate, and writes the prescription. There is no video call to schedule unless your provider or your state requires one, and follow-up messaging with your care team is included with every plan.
If you're not a candidate, you'll be told why and refunded in full.
Once-weekly compounded dual GLP-1/GIP injection for medical weight loss, with personalized dosing from licensed U.S. providers.
Start your online visitThe most common side effects are nausea, diarrhea, decreased appetite, vomiting, constipation, indigestion and stomach pain, along with fatigue and injection-site reactions. They tend to appear in the first weeks and after dose increases, and most are mild and improve as your body adjusts. Smaller meals, less fatty food and plenty of fluids help.
Serious but uncommon risks include pancreatitis, gallbladder disease, kidney injury from fluid loss, low blood sugar when combined with insulin or sulfonylureas, temporary worsening of diabetic retinopathy, severe allergic reactions and mood changes or suicidal thoughts. Tirzepatide carries a boxed warning for thyroid C-cell tumors seen in rodent studies. Seek care immediately for severe abdominal pain, trouble breathing or swallowing, or a neck lump. Report side effects to the FDA at 1-800-FDA-1088.
Do not use compounded tirzepatide if you or a family member has had medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, if you are allergic to tirzepatide, or if you are pregnant, breastfeeding or planning a pregnancy. Tell your provider about pancreatitis, gallbladder or kidney disease, diabetic eye disease, depression, and every medication you take: tirzepatide slows the absorption of oral drugs, and oral birth control may be less reliable for four weeks after starting and after each dose increase. Do not combine with another GLP-1 medication. Compounded medications are not FDA-approved. Prescription only; not available in all states.
This page is for informational purposes and does not replace a consultation with a licensed provider. Compounded medications are not reviewed by the FDA for safety, effectiveness, or quality. Brand names are trademarks of their respective owners; GobyMeds is not affiliated with them.
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