Compounded medications are prepared by state-licensed pharmacies. Prescription only — available if a licensed provider determines treatment is appropriate after your online visit. Not available in all states.Pricing and dose progression vary by bundle and are subject to availability and final treatment selection.
Mitochondrial-derived peptide MOTS-c injection
MOTS-c is for adults with insulin resistance or prediabetes under a provider's care, people with stubborn body fat or a metabolism that slowed with age, and anyone who trains consistently but recovers and progresses more slowly than they used to. It is a natural companion to a compounded semaglutide or compounded tirzepatide plan, supporting energy and muscle metabolism while appetite is reduced, and to sermorelin or NAD+ for longevity-focused patients.
It is not for use during pregnancy or breastfeeding, or for people with active cancer. Tell your provider about diabetes medication, especially metformin and insulin. Your provider reviews your history during the online visit and may suggest baseline labs so you can measure progress.
No insurance, no membership fees, no auto-renewal.
Exercise improves metabolism largely by activating AMPK, the energy sensor inside your cells that tells muscle to pull in glucose and burn fat. MOTS-c activates AMPK directly, and in animal studies it did what that implies: it improved insulin sensitivity, increased glucose uptake into skeletal muscle independent of insulin, increased fat burning, prevented diet-induced weight gain, and restored physical performance in older animals. Under metabolic stress MOTS-c also moves into the cell nucleus and switches on adaptive genes, a rare example of mitochondria signaling back to the cell's command center.
MOTS-c has also been studied for bone, where it stimulates osteoblasts and prevented bone loss in an animal model of menopause, and it promotes the growth of new mitochondria. In people, circulating MOTS-c falls with age and rises with exercise, and human trials are only beginning. Your provider will set expectations accordingly: this is a way to get more from the training and nutrition you already do, not a substitute for them.
Your provider sets a dose, typically 5 mg injected under the skin two to three times a week on non-consecutive days, for a cycle of four to eight weeks. Many people dose in the morning or before a workout. If you take metformin or other diabetes medication, your provider will coordinate, since MOTS-c acts on the same pathway and can lower blood sugar.
MOTS-c arrives as a lyophilized powder you reconstitute with the included bacteriostatic water and keep refrigerated. Your kit includes insulin-type syringes, swabs, and step-by-step mixing instructions.
Support
Every GobyMeds plan comes with people behind it: a licensed provider, a U.S.-based care team, and a patient portal that keeps everything in one place.
U.S.-based care team, around the clock. Outside staffed hours you'll hear back within about 12 hours.
Chat on the site, email customersupport@gobymeds.com, or call +1 866 785 9869.
A licensed U.S. provider reviews your visit within one business day, then stays with you: follow-ups, dose adjustments, and answers to your questions are included in every plan.
Your patient portal holds your messages, orders, tracking, and reorders in one place. Message your care team any time.
Open the portalPatients who've been where you are, and the care team alongside them.
Join the GobyMeds communityWeeks 1–2. You settle into two or three doses a week; many people report steadier daytime energy and better workout tolerance early.
Weeks 3–4. Recovery between sessions and endurance commonly improve; if you track fasting glucose, this is when changes may start to show.
Weeks 5–8. Changes in body composition, when they happen, build over a full cycle alongside training and nutrition. Your provider reviews labs and progress and plans the next cycle.
Ongoing. MOTS-c is typically used in repeated cycles as metabolic support. A typical path, not a promise; your provider adjusts the plan with you.
Animal studies have not shown toxicity, liver, or kidney effects at therapeutic doses, and people most often report only mild injection-site redness, a brief flush, or transient tiredness. Because MOTS-c improves glucose uptake it can lower blood sugar, which matters if you take diabetes medication. The long-term effects of activating AMPK with a peptide are not yet studied in large human trials, and that is the honest state of the evidence. Compounded MOTS-c is not FDA-approved. Report side effects to your care team and to the FDA at 1-800-FDA-1088.
Do not use MOTS-c if you are pregnant, planning a pregnancy, or breastfeeding, if you have active cancer, or if you have a known allergy to the formulation. Tell your provider about diabetes and diabetes medication (metformin, insulin, sulfonylureas), kidney or liver disease, and all medications and supplements you take. Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. Prescription only; not available in all states. Never share needles or vials.
This page is for informational purposes and does not replace a consultation with a licensed provider. Compounded medications are not reviewed by the FDA for safety, effectiveness, or quality. Brand names are trademarks of their respective owners; GobyMeds is not affiliated with them.
Answers from the GobyMeds care team. Still have a question? Ask your provider during your online visit, chat with us on the site, or call +1 866 785 9869 — U.S.-based, around the clock.
MOTS-c is a 16-amino-acid peptide encoded by your mitochondria, the energy-producing part of every cell. It was discovered in 2015 and is often called an "exercise mimetic" because it switches on the same metabolic pathway (AMPK) that exercise does, improving how muscle takes up glucose and burns fat. Levels fall with age and rise with exercise. At GobyMeds it is prescribed as a compounded subcutaneous injection prepared by a licensed U.S. pharmacy. It is not FDA-approved.
People ask about MOTS-c for metabolic support: insulin resistance, stubborn body fat, low energy, and performance that has dropped off with age. The FDA advisory committee reviewed it in 2026 for obesity and osteoporosis. In animal studies it prevented diet-induced weight gain, improved insulin sensitivity, protected bone, and restored physical performance in older animals; human trials are just beginning, so your provider will set realistic expectations.
MOTS-c is a small injection under the skin, most often 5 mg two to three times a week in published protocols, for a cycle of four to eight weeks. Many people dose in the morning or before a workout. It arrives as a powder you mix with the included water. Your provider sets your dose and schedule.
Yes, and it is a natural pairing. GLP-1 medication reduces appetite and intake; MOTS-c works on the other side of the equation, helping muscle use glucose and burn fat and supporting the energy and performance that can dip in a calorie deficit. Tell your provider everything you take, including metformin, which acts on the same AMPK pathway, so they can coordinate dosing.
No. "Exercise mimetic" means it activates some of the same cellular pathways, not that it delivers the same results. MOTS-c is best thought of as a way to get more out of the training and nutrition you are already doing, especially if age or insulin resistance has made progress harder.
Animal studies have not shown toxicity at therapeutic doses, and people most often report only mild injection-site redness, a brief flush, or transient tiredness. Long-term human data are limited. Your provider will want to know about diabetes medication, since MOTS-c can lower blood sugar, and about any history of cancer. Compounded MOTS-c is not FDA-approved.
Many people report steadier energy and better workout tolerance within two to four weeks. Changes in body composition and fasting glucose, if they happen, tend to show over a full four- to eight-week cycle alongside training. Your provider may suggest baseline and follow-up labs so you can measure the difference rather than guess.
Peptides are short chains of amino acids, the same building blocks that make up proteins. Your body already makes thousands of them to carry signals between cells: to start repair after an injury, to release growth hormone during sleep, to calm inflammation, or to tell your mitochondria to make more energy. Peptide therapy uses lab-made copies or fragments of those signals, prescribed at a specific dose, to support a process your body already knows how to run. Semaglutide and tirzepatide are peptides too, which is why GobyMeds already has years of experience prescribing and shipping them.
Compounded peptides are not FDA-approved, and no compounded medication is. In July 2026 the FDA's Pharmacy Compounding Advisory Committee voted to recommend adding BPC-157, KPV, TB-500, MOTS-c, Semax, and Epitalon to the list of substances that licensed 503A pharmacies may compound, and in October 2026 HHS published an interim enforcement-discretion policy covering those six peptides while the FDA completes formal rulemaking. GobyMeds offers a peptide only when a licensed U.S. pharmacy can lawfully compound it for your prescription under that policy and your state's rules. Compounded drugs are not evaluated by the FDA for safety, effectiveness, or quality.
Yes. Every peptide at GobyMeds is prescription-only. You complete a short online visit, a licensed U.S. provider reviews your history and goals, usually within one business day, and prescribes the peptide only if it is appropriate for you. The pharmacy then compounds it for your prescription and ships it to your door. If a provider decides treatment isn't right for you, you receive a full refund.
Websites selling "research use only" peptides ship unregulated powders with no prescription, no provider, no sterility testing you can verify, and no one to call when something feels off. GobyMeds is LegitScript-certified: a licensed provider evaluates you first, a licensed U.S. compounding pharmacy prepares your medication to a prescription, and your care team follows up with you throughout. You also get transparent pricing, a supply kit with instructions, and free shipping, with no membership fee.
Most peptides are broken down in the stomach, so the most reliable route is a small injection under the skin with a tiny insulin-type syringe, the same kind used for GLP-1 weight-loss medication. The needle is very fine, the volume is small, and most people say it is easier than expected after the first time. Your kit includes syringes, alcohol swabs, and step-by-step instructions, and your care team can walk you through the first dose. Semax is the exception: it is a nasal spray.
Often, yes. Peptides are frequently prescribed alongside each other (BPC-157 with TB-500 for recovery, for example) and alongside GLP-1 medication, NAD+, sermorelin, or testosterone therapy. Tell your provider about everything you take, including supplements, and they will coordinate the plan and the timing. Your provider will work with you to adjust your medication for your goals.
No lab work is required to start. Your provider reviews your health history during the online visit and may ask for recent results if something in your history warrants it. For a few peptides your provider may suggest baseline bloodwork so progress can be measured, for example fasting glucose or inflammatory markers; that is optional and you can use your own doctor's results.
Your medication ships free from the pharmacy in insulated, cold-chain packaging in as little as 3 days after provider approval; most orders arrive within two to five business days. Injectable peptides arrive as a sterile vial, either ready to use or as a powder with the water needed to mix it, and should be kept in the refrigerator. Nasal sprays are stored according to the label. Full storage and mixing instructions are in your kit and in the patient portal.
Each peptide page shows its plan prices up front. The price you see is the price you pay: it includes the online visit, provider follow-ups, the medication, your supply kit, and shipping. There is no membership fee, no insurance requirement, and no auto-renewal, and you are not charged until your medication ships.
The peptides GobyMeds offers are copies or fragments of molecules your body already makes, and most people experience few side effects. The most common are mild and temporary: redness or a small bump at the injection site, brief flushing, headache, or nausea. Human research on most peptides is still limited, which is why a provider screens your history first and why we are candid about what the evidence does and does not show. Compounded peptides are not FDA-approved. Report side effects to your care team and to the FDA at 1-800-FDA-1088.
If a GobyMeds provider decides a prescription isn't appropriate for you, you receive a 100% refund of the medication price (lab fees, where they apply, are not refunded). Once your order has been sent to our medical partners or to the pharmacy for fulfillment we will do our best to accommodate changes or cancellations, but we can't guarantee them, and in some cases an adjustment or cancellation carries a $50 medical consultation fee.
Because of regulations covering prescription medication, we are unable to accept returned medication for a refund.
No insurance is needed and GobyMeds does not bill insurance. The price you see is the price you pay, with provider consultation and shipping included and no membership fee.
HSA and FSA cards are accepted at checkout, and we can provide a letter of medical necessity if your plan administrator asks for one.
You answer a short health questionnaire and upload a photo ID. A licensed U.S. provider reviews your history, usually within one business day, confirms the treatment is appropriate, and writes the prescription. There is no video call to schedule unless your provider or your state requires one, and unlimited follow-up messaging with your care team in the patient portal is included with every plan.
If you're not a candidate, you'll be told why and refunded in full.
Compounded MOTS-c subcutaneous injection, the mitochondrial “exercise mimetic” peptide, for metabolic support and insulin sensitivity, prescribed online.
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