Common Side Effects of NAD+ Therapy

Common Side Effects of NAD+ Therapy

Curious about NAD+ side effects? Learn what to expect from NAD+ injections and nasal sprays. Discover why the side effects are normally very mild, temporary, and easily manageable.

Common Side Effects of NAD+ Therapy: What to Expect with Injections and Sprays

Starting a new wellness therapy is exciting, but you might have questions about what to expect. When it comes to NAD+, many people ask, "Are there side effects?"

Here at GobyMeds, we believe in providing transparent, straightforward answers so you can feel empowered in your health choices.

The short answer is yes, some side effects can occur - but  for the vast majority of users, they are normally mild and brief. This article will walk you through what to expect with the two different delivery types we offer: subcutaneous NAD+ injections and NAD+ nasal sprays.

At GobyMeds, NAD+ is offered as a subcutanous injection or a nasal spray.

Is NAD+ Therapy Safe?

First, NAD+ (Nicotinamide Adenide Dinucleotide) is a molecule your body already knows and relies on. It’s a natural coenzyme in every cell to power your metabolism. NAD+ therapy just supplements your own supply, which naturally declines with age.

For most people, NAD+ therapy is very well-tolerated. When side effects do happen, the key takeaway is that they are normally mild, temporary, and easily manageable. Think of them less as "side effects" and more as your body's small response to a  cellular tune-up.

Did you know this? NAD+ is such an important molecule in our body that rapidly declines with age.

What to Expect with Subcutaneous NAD+ Injections

When you administer NAD+ via a subcutaneous injection (a small shot just under the skin), the most common reports are minor, localized reactions (this just means specific to the site of your injection).

  • Minor Redness, Itching, or Swelling: You might notice a small, red, or itchy bump at the injection site. This is a perfectly normal, minor immune response that typically vanishes within a few hours.
  • A Feeling of Warmth or Flushing: NAD+ temporarily widens your blood vessels, which is a sign it's working to improve circulation. This can create a brief, gentle feeling of warmth or flushing. This sensation is harmless and usually passes in minutes.
  • Very Mild Nausea or Stomach Discomfort: On occasion, some users report feeling a bit of light-headedness or an upset stomach, especially when first starting. This is normally very mild and fades quickly as your body gets used to the therapy.

What to Expect with NAD+ Nasal Sprays

NAD+ nasal sprays are known for being exceptionally gentle. When side effects occur, they are almost always minor and confined to the nasal passages.

  • Slight Nasal Irritation: The delicate lining of your nose might feel a bit ticklish or dry immediately after using the spray.
  • Runny Nose or a Sneeze: It's natural to have a temporary runny nose or the urge to sneeze right after administration. This is just your body's response to the mist and usually resolves in a minute or two.
  • Mild "Head Rush": Similar to injections, the vasodilating effects of NAD+ can sometimes cause a brief, very mild headache or a "head rush" feeling, which disappears quickly.

Tips for a Smooth Experience

You can play an active role in ensuring your experience with NAD+ is as comfortable as possible.

  1. Start Low, Go Slow: The most effective way to prevent any discomfort is to start with a lower dose. This allows your body to acclimate gently and is our standard recommendation. Your GobyMeds provider and our team will help you get started on the correct first dose for you.
  2. Rotate Injection Sites: For subcutaneous injections, simply rotating the location (e.g., different sides of the abdomen) prevents any single spot from becoming irritated.
  3. Stay Hydrated: Drinking plenty of water is a simple trick that helps minimize any potential for headaches or nausea.
  4. Talk to Us: Your GobyMeds provider is here to help. If you have any questions or experience a side effectyou're unsure about, reach out. We are here to help you adjust your dose and guide you.

Note: You can always talk to your GobyMeds provider in your patient portal under "MEDICAL CHAT".

Your Wellness Journey, Supported

Ultimately, NAD+ therapy is a safe way to support your cellular health. By understanding what to expect, you can feel confident knowing that the side effects are normally very mild, manageable, and a clear sign that you're actively refueling your body from within.

Have more questions about starting NAD+? Our clinical team is here to give you the clear answers and unwavering support you deserve. Just log in to your patient portal and head to your Medical Chat if you have a question regarding your specific prescription and/or health or click on the Customer Support chat bubble in the lower right hand corner for general questions about NAD+, your order, shipping, GobyMeds policies, etc. We are happy to help!

Ready to see if NAD+ is a good fit for you? Head to my.gobymeds.com to get started today!

Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional about your specific health needs and before beginning any new treatment.

No hidden fees, no membership fees, Tailored to you - simple guaranteed.

Our Programs & Products

Free Express Shipping & Consultation On Every Order

Compounded Semaglutide
GLP-1  For Weight Loss
From $117/m*
In Stock
Safety Information
Compounded Tirzepatide
GLP-1/GIP Weight Loss
Starting at $166/m*
In Stock
Safety Information
Zepbound®
$1399/m
Limited supply
Safety Information
Wegovy®
$1695/m
Limited supply
Safety Information
Boost Lean Muscle Mass
Sermorelin
Starting at $199/m
In Stock
Safety Information
Boost Lean Muscle Mass
Sermorelin
Starting at $199/m
In Stock
Safety Information
Anti-Aging + Boost Vitality
NAD+
Starting at $199/m
In Stock
Safety Information
Anti-Aging + Skin Health
Glutathione
Starting at $119/m
In Stock
Safety Information
Energy+ Cognitive/Mood Boost
MIC/B12
Starting at $119/m
In Stock
Safety Information
The lowest prices shown may reflect multi-month plans or introductory bundles. Products, pricing and availability may vary by geographical location. Prescription medications are available only if deemed appropriate following an online consultation with a licensed healthcare provider. Providers may prescribe compounded medications based on patient needs or due to medication shortages. Please note that compounded medications are not reviewed or approved by the FDA for safety or efficacy. Individual results may vary. Actual product packaging may differ from images shown.
Compounded Semaglutide & Compounded Tirzepatide

Weight Loss Programs

Compounded Semaglutide (GLP-1) Starter Plan - 12-Week Bundle
$299
Perfect for first-time patients beginning their GLP-1 journey.
JUMPSTART PROMO PRICE: $279*
($93/month)*
Compounded Semaglutide (GLP-1) - 12-Week Bundle
$399+
Ideal for patients at a higher non-starter dose or wanting to titrate up to a higher therapeutic dose.
0.2 to 1.0 mg - from $399
1.2 to 2.3 mg - from $499
JUMPSTART PROMO PRICE: $439*
($146/month)*
Compounded Semaglutide (GLP-1) - 1 Month
$169
One month at any dosage.
JUMPSTART PROMO PRICE: $159*
*Jumpstart Promo Pricing
This price is available now through December 31st, 2025 with code JUMPSTART20 Click here for more details.
Compounded Tirzepatide (GLP-1/GIP)
Starter Plan - 3 month
$399
Perfect for first-time patients beginning their weight loss journey.
JUMPSTART PROMO PRICE: $399*
($133/month)*
Compounded Tirzepatide (GLP-1/GIP)
12-Week Bundle
$499+
Ideal for patients at a higher non-starter dose or wanting to titrate up to a higher therapeutic dose.
1.5 to 6 mg - from $499
9 to 13.5 mg - from $599
JUMPSTART PROMO PRICE: $479+*
(price dependent on dose)
Compounded Tirzepatide (GLP-1/GIP)
Single Month
$299
One month at any dosage.
JUMPSTART PROMO PRICE: $279*
*Jumpstart Promo Pricing
This price is available now through December 31st, 2025 with code JUMPSTART20 Click here for more details.
Zepbound®
$1399 / month
Zepbound® is a GLP-1/GIP medication designed to help adults achieve clinically proven weight-loss results.
Wegovy®
$1695 / month
Wegovy® is a GLP-1 medication designed to help adults achieve clinically proven weight-loss results.
Share this post