Semaglutide vs. Tirzepatide - What’s the Difference?

If you're exploring GLP-1-based medications for weight or metabolic health, you’ve likely come across semaglutide and tirzepatide. Both are prescription treatments offered at GobyMeds in compounded forms - prepared by licensed compounding pharmacies and available only with a prescription from a licensed provider.

Let’s explore the differences in how they work, how they’re priced, and what patients may want to consider when speaking with their healthcare provider.

Disclaimer: Compounded semaglutide and compounded tirzepatide are not FDA-approved. They must be prescribed by a licensed provider and are not reviewed by the FDA for safety, effectiveness, or manufacturing quality.

Popularity and Background

Semaglutide has been used in GLP-1 therapy for several years and is one of the more well-known options, originally studied for type 2 diabetes and later evaluated for weight-related applications.

Tirzepatide is a newer agent that activates both GLP-1 and GIP receptors. This dual action is being researched for its potential to support greater improvements in appetite signaling and metabolic function.

Accessing Compounded Medications

At GobyMeds, we offer both medications in compounded formulations. Patients can choose from convenient single-month or multi-month bundles, depending on their treatment plan and provider guidance.

Mechanism and Research

Semaglutide is a GLP-1 receptor agonist. It mimics the hormone GLP-1 to help support insulin regulation, slow gastric emptying, and promote a feeling of fullness.

Tirzepatide combines GLP-1 and GIP receptor activation. GIP is another hormone that may further enhance glucose and fat metabolism when paired with GLP-1 activity.

FDA-reviewed studies have evaluated these medications in their branded forms:

• Semaglutide showed an average weight reduction of ~15% over 68 weeks.
• Tirzepatide demonstrated an average reduction of ~20% over 72 weeks.

These findings reflect outcomes from FDA-approved products and may not translate directly to compounded versions.

Side Effects

Side effects can vary, and both medications may include:

• Nausea
• Diarrhea
• Constipation
• Fatigue or GI discomfort

Some users report that side effects diminish with continued use and gradual dose increases, which are common strategies in GLP-1 therapy.

Choosing Between Compounded GLP-1 Options

The best choice depends on your health history, response to medications, and preferences. A licensed GobyMeds provider can help guide you in selecting the option that aligns with your goals.

Start with a Personalized Plan

If you’re interested in exploring compounded GLP-1 medications like semaglutide or tirzepatide, GobyMeds offers a convenient telehealth experience to help you get started.

Visit GobyMeds.com to learn more, schedule your consultation, and access personalized care.

Note: This article is for educational purposes only. Always speak with a licensed provider before starting any new medication.

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