Sermorelin acetate 500-1000 mcg troche / sublingual tablet
Compounded medications are prepared by state-licensed pharmacies. Prescription only — available if a licensed provider determines treatment is appropriate after your online visit. Not available in all states.
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As we age, the pituitary releases less growth hormone, and the decline shows up as slower recovery, thinner skin, more body fat, lighter sleep and lower energy. Sermorelin is an analog of growth-hormone-releasing hormone (GHRH), the signal the hypothalamus sends to the pituitary. Taken at bedtime, it prompts the pituitary to release growth hormone in the natural pulses that occur during deep sleep, raising IGF-1 and supporting muscle repair, fat metabolism, collagen production and sleep quality.
The troche form delivers sermorelin through the buccal mucosa, the thin, blood-rich lining inside the cheek, so it enters the bloodstream without passing through the stomach, where peptides are broken down. Because your own feedback loops stay in control, sermorelin is regarded as a gentler alternative to injecting synthetic HGH, which overrides that rhythm. Sermorelin was previously FDA-approved for pediatric growth hormone deficiency; the compounded forms prescribed to adults today are prepared by a licensed U.S. pharmacy and are not FDA-approved.
Your provider prescribes 500–1000 mcg nightly, typically five nights a week. Place the troche between your cheek and gum at bedtime and let it dissolve completely over several minutes without chewing or swallowing; avoid food and drink for 15 minutes before and after so it absorbs through the mouth lining. Store as directed on the label. A 1-month plan covers 4 weeks and a 3-month plan covers 12.
Sermorelin is for adults dealing with fatigue, slow recovery, poor sleep or body-composition changes that come with declining growth hormone; for people focused on longevity, performance or metabolic health; and for those recovering from burnout, illness or chronic stress. It's often combined with NAD+ or with a GLP-1 weight-loss plan to help preserve lean muscle. The troche is for anyone who wants the benefits of sermorelin without injections and is comfortable with a few minutes of dissolve time at bedtime.
It is not for anyone with active cancer or a history of certain tumors, or during pregnancy or breastfeeding. Your provider reviews your history during the online visit. If you want the most portable form, the film strip dissolves in about a minute; if you want the most studied route, choose the injection.
Month 1. Deeper, more restful sleep and better daytime energy and stamina are the first changes most people notice.
Months 2–3. Recovery after exercise speeds up, skin elasticity and nail strength improve, and mental focus sharpens as growth hormone pulses normalize.
Months 4–6. Fat reduction and lean-muscle gains become visible with training, along with fuller hair and sustained vitality. Full results typically take three to six months.
Ongoing. Benefits continue with consistent nightly use; your provider can adjust the dose or form at any follow-up.
Answers from the GobyMeds care team. Still have a question? Your provider can answer it during your online visit.
Place the troche between your cheek and gum at bedtime and let it dissolve completely over several minutes without chewing or swallowing it. Avoid eating or drinking for 15 minutes afterward so the medication absorbs through the mouth lining rather than the stomach.
Sermorelin is a growth-hormone-releasing hormone analog: it prompts your pituitary gland to release more of your own growth hormone, in the natural pulses that happen during deep sleep, and your body's feedback loops still apply. HGH therapy injects synthetic growth hormone directly and overrides that rhythm. Sermorelin is generally considered the gentler approach, and GobyMeds does not prescribe HGH.
At bedtime, on an empty stomach, typically five nights a week. Growth hormone is released mainly during deep sleep, so dosing before bed works with that cycle; eating sugar or carbohydrates right before a dose blunts the response.
Deeper sleep and better daytime energy are usually the first changes, often within the first month. Improvements in recovery, skin and body composition build gradually, with the fuller effect on lean muscle and fat reduction typically taking three to six months of consistent use.
Sermorelin works with your body's own regulation rather than replacing growth hormone, which is why it's regarded as a lower-risk alternative to HGH. Most people tolerate it well; regular check-ins with your provider are recommended, and it's not used in people with active cancer or during pregnancy. Compounded sermorelin is not FDA-approved.
Most users experience few side effects. The most common are redness or swelling at an injection site, facial flushing, headache and dizziness; oral forms occasionally cause mild mouth or throat irritation. Joint aches, fluid retention or tingling in the hands can signal the dose is higher than you need. Seek care immediately for signs of a severe allergic reaction.
The injection is the most studied route and the most economical on a 3-month plan. The troche dissolves slowly in the cheek and the film strip dissolves on the tongue; both are needle-free and absorbed through the lining of the mouth. The strip is the most portable and discreet. Your provider can start you on any form and switch you later.
If a GobyMeds provider decides a prescription isn't appropriate for you, you receive a 100% refund of the medication price (lab fees, where they apply, are not refunded). Once your order has been sent to our medical partners or to the pharmacy for fulfillment we will do our best to accommodate changes or cancellations, but we can't guarantee them, and in some cases an adjustment or cancellation carries a $50 medical consultation fee.
Because of regulations covering prescription medication, we are unable to accept returned medication for a refund.
No insurance is needed and GobyMeds does not bill insurance. The price you see is the price you pay, with provider consultation and shipping included and no membership fee.
HSA and FSA cards are accepted at checkout, and we can provide a letter of medical necessity if your plan administrator asks for one.
You answer a short health questionnaire and upload a photo ID. A licensed U.S. provider reviews your history, confirms the treatment is appropriate, and writes the prescription. There is no video call to schedule unless your provider or your state requires one, and follow-up messaging with your care team is included with every plan.
If you're not a candidate, you'll be told why and refunded in full.
Compounded sermorelin as a dissolving troche or sublingual tablet (500-1000 mcg), needle-free.
Start your online visitMost users experience few side effects. The most common are facial flushing, headache, dizziness and, with the injection, redness or swelling at the injection site; oral forms occasionally cause mild mouth or throat irritation. Joint aches, fluid retention, tingling in the hands or increased hunger can signal the dose is higher than you need and resolve with adjustment. Seek care immediately for signs of a severe allergic reaction or worsening shortness of breath. Compounded sermorelin is not FDA-approved. Report side effects to the FDA at 1-800-FDA-1088.
Do not use sermorelin if you have active cancer or a history of certain tumors (unless cleared by your oncologist), a known allergy to sermorelin or its ingredients, or if you are pregnant, planning a pregnancy or breastfeeding. Tell your provider about pituitary tumors or surgery, thyroid disease, diabetes, sleep apnea or breathing problems, and all medications and supplements you take; corticosteroids and thyroid medication can affect the response. Compounded drug products are not approved or evaluated for safety, effectiveness or quality by the FDA. Prescription only; not available in all states.
This page is for informational purposes and does not replace a consultation with a licensed provider. Compounded medications are not reviewed by the FDA for safety, effectiveness, or quality. Brand names are trademarks of their respective owners; GobyMeds is not affiliated with them.
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